Acyclovir cream

Acyclovir cream is a topical medication that contains the active ingredient acyclovir, which belongs to a class of drugs called antivirals. It is used to treat recurrent outbreaks of cold sores (herpes labialis) caused by the herpes simplex virus (HSV). Here is some information about acyclovir cream:

ACYCLOVIR

Treatment of Cold Sores

Acyclovir cream is primarily prescribed for the treatment of cold sores, which are small blisters that typically appear on or around the lips. It works by inhibiting the growth and spread of the herpes simplex virus, reducing the severity and duration of outbreaks.

Application and Dosage

Acyclovir cream is applied topically to the affected area of the skin. It should be applied as early as possible during the onset of a cold sore, usually every 3 to 4 hours, up to 5 times a day, for a period of 4 to 5 days. It is important to wash hands before and after applying the cream to avoid spreading the infection.

Effectiveness and Prevention

Acyclovir cream is most effective when used at the first sign of a cold sore, such as tingling, itching, or redness. It may help to shorten the healing time and reduce the severity of symptoms. However, it does not cure the herpes simplex virus or prevent future outbreaks.

Precautions and Potential Side Effects

Acyclovir cream is generally well-tolerated when used as directed. Common side effects may include mild stinging or burning at the application site. If any severe or persistent side effects occur, it is important to seek medical attention.

It is important to note that acyclovir cream is for external use only and should not be applied to the inside of the mouth, eyes, or genital area. Avoid contact with these areas and mucous membranes. If accidental contact occurs, rinse thoroughly with water.

Consultation with Healthcare Professional

Acyclovir cream is available over the counter in some countries, while in others, it may require a prescription. It is still recommended to consult with a healthcare professional, such as a doctor or dermatologist, before starting treatment. They can provide specific instructions based on your individual situation and determine the most appropriate course of action.

WARNING: Please consult with a healthcare professional or doctor for personalized advice and guidance regarding the use of acyclovir cream or any other medication for the treatment of cold sores caused by the herpes simplex virus. They will be able to provide specific instructions based on your medical history and individual needs.

References

  1. Jump up to:a b c “Aciclovir”Drugs.comArchived from the original on 23 September 2015. Retrieved 6 September 2015.
  2. Jump up to:a b c d “Zovirax (acyclovir) dosing, indications, interactions, adverse effects, and more”Medscape Reference. WebMD. Archived from the original on 19 February 2014. Retrieved 5 February 2014.
  3. ^ Kevin ES. “The Aciclovir” (in German). Kevin. Retrieved 25 May 2017.
  4. Jump up to:a b de Clercq E, Field HJ (5 October 2005). “Antiviral prodrugs – the development of successful prodrug strategies for antiviral chemotherapy”. British Journal of Pharmacology. Vol. 147, no. 1. Wiley-Blackwell (published January 2006). pp. 1–11. doi:10.1038/sj.bjp.0706446PMC 1615839PMID 16284630.
  5. Jump up to:a b c d e f g h i j “Acyclovir”. The American Society of Health-System Pharmacists. Archived from the original on 2015-01-05. Retrieved Jan 1, 2015.
  6. ^ Rafailidis PI, Mavros MN, Kapaskelis A, Falagas ME (November 2010). “Antiviral treatment for severe EBV infections in apparently immunocompetent patients”. Journal of Clinical Virology49 (3): 151–157. doi:10.1016/j.jcv.2010.07.008PMID 20739216.
  7. ^ “Prescribing medicines in pregnancy database”Australian Government. 3 March 2014. Archived from the original on 8 April 2014. Retrieved 22 April 2014.
  8. ^ Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 59. ISBN 9781284057560.
  9. ^ “Acyclovir use while Breastfeeding”. Mar 10, 2015. Archived from the original on 5 March 2016. Retrieved 8 March 2016. Even with the highest maternal dosages, the dosage of acyclovir in milk is only about 1% of a typical infant dosage and would not be expected to cause any adverse effects in breastfed infants
  10. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 504. ISBN 9783527607495.
  11. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  12. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  13. ^ “The Top 300 of 2020”ClinCalc. Retrieved 7 October 2022.
  14. ^ “Acyclovir – Drug Usage Statistics”ClinCalc. Retrieved 7 October 2022.
  15. Jump up to:a b c d Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3.
  16. ^ Joint Formulary Committee (2013). British National Formulary (BNF) (65 ed.). London: Pharmaceutical Press. ISBN 978-0-85711-084-8.
  17. ^ Elad S, Zadik Y, Hewson I, Hovan A, Correa ME, Logan R, et al. (August 2010). “A systematic review of viral infections associated with oral involvement in cancer patients: a spotlight on Herpesviridea”. Supportive Care in Cancer18 (8): 993–1006. doi:10.1007/s00520-010-0900-3PMID 20544224S2CID 2969472.
  18. ^ Gershburg E, Pagano JS (August 2005). “Epstein-Barr virus infections: prospects for treatment”. The Journal of Antimicrobial Chemotherapy56 (2): 277–281. CiteSeerX 10.1.1.320.6721doi:10.1093/jac/dki240PMID 16006448.
  19. ^ De Paor M, O’Brien K, Fahey T, Smith SM (December 2016). “Antiviral agents for infectious mononucleosis (glandular fever)”The Cochrane Database of Systematic Reviews2016 (12): CD011487. doi:10.1002/14651858.CD011487.pub2PMC 6463965PMID 27933614.
  20. ^ Chen N, Li Q, Yang J, Zhou M, Zhou D, He L (February 2014). “Antiviral treatment for preventing postherpetic neuralgia”. The Cochrane Database of Systematic Reviews2 (2): CD006866. doi:10.1002/14651858.CD006866.pub3PMID 24500927.
  21. Jump up to:a b Wilhelmus KR (January 2015). “Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis”The Cochrane Database of Systematic Reviews1: CD002898. doi:10.1002/14651858.CD002898.pub5PMC 4443501PMID 25879115.
  22. ^ Worrall G (January 1996). “Acyclovir in recurrent herpes labialis”BMJ312 (7022): 6. doi:10.1136/bmj.312.7022.6PMC 2349724PMID 8555890Archived from the original on 2007-05-15. – Editorial
  23. ^ Spruance SL, Nett R, Marbury T, Wolff R, Johnson J, Spaulding T (July 2002). “Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled, multicenter clinical trials”Antimicrobial Agents and Chemotherapy46 (7): 2238–2243. doi:10.1128/aac.46.7.2238-2243.2002PMC 127288PMID 12069980.
  24. ^ Mascolinli M, Kort R (June 2010). “5th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention: summary of key research and implications for policy and practice – biomedical prevention”Journal of the International AIDS Society13 (Suppl 1): S4. doi:10.1186/1758-2652-13-S1-S4PMC 2880255PMID 20519025.
  25. Jump up to:a b c “Acyclovir label” (PDF). GSK. FDA. 2005. Archived from the original (PDF) on 2017-09-08.
  26. ^ “Drugs for non-HIV viral infections”. Treatment Guidelines from the Medical Letter3 (32): 23–32. April 2005. PMID 15767977.
  27. ^ Kaplan JE, Benson C, Holmes KK, Brooks JT, Pau A, Masur H (April 2009). “Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America”MMWR. Recommendations and Reports58 (RR-4): 1–207, quiz CE1–4. PMID 19357635.
  28. Jump up to:a b c d “PRODUCT INFORMATION NAME OF THE DRUG OZVIR TABLETS” (PDF). TGA eBusiness Services. Ranbaxy Australia Pty Ltd. 26 August 2011. Archived from the original on 20 August 2016. Retrieved 6 February 2014.
  29. ^ Centers for Disease Control and Prevention. (January 2006). Epidemiology and prevention of vaccine-preventable diseases (9th ed.). Public Health Foundation. pp. 171–192.
  30. ^ Gartner LM, Morton J, Lawrence RA, Naylor AJ, O’Hare D, Schanler RJ, Eidelman AI (February 2005). “Breastfeeding and the use of human milk”. Pediatrics115 (2): 496–506. doi:10.1542/peds.2004-2491PMID 15687461S2CID 5791615.
  31. ^ Razonable RR (October 2011). “Antiviral drugs for viruses other than human immunodeficiency virus”Mayo Clinic Proceedings86 (10): 1009–1026. doi:10.4065/mcp.2011.0309PMC 3184032PMID 21964179.
  32. ^ Brigden D, Rosling AE, Woods NC (July 1982). “Renal function after acyclovir intravenous injection”. The American Journal of Medicine73 (1A): 182–185. doi:10.1016/0002-9343(82)90087-0PMID 6285711.
  33. ^ Sawyer MH, Webb DE, Balow JE, Straus SE (June 1988). “Acyclovir-induced renal failure. Clinical course and histology”The American Journal of Medicine84 (6): 1067–1071. doi:10.1016/0002-9343(88)90313-0PMID 3376977.
  34. ^ Helldén A, Odar-Cederlöf I, Diener P, Barkholt L, Medin C, Svensson JO, et al. (June 2003). “High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study”Nephrology, Dialysis, Transplantation18 (6): 1135–1141. doi:10.1093/ndt/gfg119PMID 12748346.
  35. ^ Berry L, Venkatesan P (December 2014). “Aciclovir-induced neurotoxicity: Utility of CSF and serum CMMG levels in diagnosis”. Journal of Clinical Virology61 (4): 608–610. doi:10.1016/j.jcv.2014.09.001PMID 25440915.
  36. ^ Chowdhury MA, Derar N, Hasan S, Hinch B, Ratnam S, Assaly R (2016). “Acyclovir-Induced Neurotoxicity: A Case Report and Review of Literature”. American Journal of Therapeutics23 (3): e941–e943. doi:10.1097/MJT.0000000000000093PMID 24942005S2CID 32983100.
  37. ^ Pottage JC, Kessler HA, Goodrich JM, Chase R, Benson CA, Kapell K, Levin S (August 1986). “In vitro activity of ketoconazole against herpes simplex virus”Antimicrobial Agents and Chemotherapy30 (2): 215–219. doi:10.1128/aac.30.2.215PMC 180521PMID 3021048.
  38. ^ GlaxoSmithKline. Zovirax® (acyclovir sodium) for injection prescribing information. Research Triangle Park, NC; 2003 Nov
  39. ^ Bach MC (February 1987). “Possible drug interaction during therapy with azidothymidine and acyclovir for AIDS”. The New England Journal of Medicine316 (9): 547. doi:10.1056/NEJM198702263160912PMID 3468354.
  40. ^ Baselt RC (2008). Disposition of toxic drugs and chemicals in man (8th ed.). Foster City, CA: Biomedical Publications. pp. 29–31. ISBN 9780962652370.
  41. ^ “VALTREX (valacyclovir hydrochloride) Caplets -GSKSource”gsksource.com. Retrieved 2019-08-02.
  42. ^ “Acyclovir (acyclovir) Capsule Acyclovir (acyclovir) Tablet [Genpharm Inc.]”DailyMed. Genpharm Inc. November 2006. Archived from the original on 21 February 2014. Retrieved 5 February 2014.
  43. ^ “Aciclovir Tablets BP 400mg – Summary of Product Characteristics (SPC)”electronic Medicines Compendium. Actavis UK Ltd. 20 August 2012. Archived from the original on 22 February 2014. Retrieved 5 February 2014.
  44. ^ Sweetman, S, ed. (7 August 2013). “Aciclovir”Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 6 February 2014.
  45. ^ Piret J, Boivin G (February 2011). “Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management”Antimicrobial Agents and Chemotherapy55 (2): 459–472. doi:10.1128/AAC.00615-10PMC 3028810PMID 21078929.
  46. ^ O’Brien JJ, Campoli-Richards DM (March 1989). “Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy”. Drugs37 (3): 233–309. doi:10.2165/00003495-198937030-00002PMID 2653790S2CID 240858022.
  47. ^ Wagstaff AJ, Faulds D, Goa KL (January 1994). “Aciclovir. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy”. Drugs47 (1): 153–205. doi:10.2165/00003495-199447010-00009PMID 7510619.
  48. ^ Karmoker JR, Hasan I, Ahmed N, Saifuddin M, Reza MS (2019). “Development and Optimization of Acyclovir Loaded Mucoadhesive Microspheres by Box -Behnken Design”Dhaka University Journal of Pharmaceutical Sciences18 (1): 1–12. doi:10.3329/dujps.v18i1.41421.
  49. ^ “Aciclovir Tablets BP 400mg – Summary of Product Characteristics (SmPC) – (emc)”www.medicines.org.uk.
  50. Jump up to:a b Schaeffer HJ, Gurwara S, Vince R, Bittner S (April 1971). “Novel substrate of adenosine deaminase”. Journal of Medicinal Chemistry14 (4): 367–369. doi:10.1021/jm00286a024PMID 5553754.
  51. ^ US patent 4199574, Schaeffer HJ, “Methods and compositions for treating viral infections and guanine acyclic nucleosides”, published 1980-04-22, assigned to Burroughs Wellcome.
  52. ^ Vardanyan R, Hruby V (2016). “34: Antiviral Drugs”. Synthesis of Best-Seller Drugs. pp. 706–708. doi:10.1016/B978-0-12-411492-0.00034-1ISBN 9780124114920S2CID 75449475.
  53. ^ Garrison T (1999). Oceanography: An Invitation to Marine Science, 3rd ed. Belmont, CA: Wadsworth Publishing Company. p. 471.
  54. ^ Sepčić K (2000). “Bioactive Alkylpyridinium Compounds from Marine Sponges”. Toxin Reviews19 (2): 139–160. doi:10.1081/TXR-100100318S2CID 84041855.
  55. ^ Laport MS, Santos OC, Muricy G (January 2009). “Marine sponges: potential sources of new antimicrobial drugs”. Current Pharmaceutical Biotechnology10 (1): 86–105. doi:10.2174/138920109787048625PMID 19149592.
  56. ^ Elion GB, Furman PA, Fyfe JA, de Miranda P, Beauchamp L, Schaeffer HJ (December 1977). “Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine”Proceedings of the National Academy of Sciences of the United States of America74 (12): 5716–5720. Bibcode:1977PNAS…74.5716Edoi:10.1073/pnas.74.12.5716PMC 431864PMID 202961.
  57. ^ US 4146715, Schaeffer HJ, “2-Amido-9-(2-acyloxyethoxymethyl)hypoxanthines”, issued 27 March 1979, assigned to Burrough Wellcome Co.
  58. ^ Vince R (2008). “A brief history of the development of Ziagen”. Chemtracts21: 127–134.
  59. ^ “Valacyclovir Hydrochloride Monograph for Professionals”Drugs.com. American Society of Health-System Pharmacists. Retrieved 17 March 2019.
  60. ^ “Drug Approval Package: Acyclovir and Hydrocortisone NDA #022436”U.S. Food and Drug Administration (FDA). 13 December 2019. Archived from the original on 13 December 2019. Retrieved 13 December 2019. PUBLIC DOMAIN This article incorporates text from this source, which is in the public domain.
  61. ^ “Xerese- acyclovir and hydrocortisone cream”DailyMed. 12 December 2019. Archived from the original on 13 December 2019. Retrieved 12 December 2019.