Flagyl is a brand name for the medication metronidazole, which is an antibiotic and antiprotozoal drug. It is commonly prescribed for the treatment of various bacterial and parasitic infections. Here is some information about Flagyl:


Treatment of Bacterial Infections

Flagyl (metronidazole) is used to treat a wide range of bacterial infections, including infections of the gastrointestinal tract, such as bacterial diarrhea and gastritis. It is also effective against certain infections in the reproductive system, respiratory system, skin, and other areas of the body.

Treatment of Protozoal Infections

In addition to bacterial infections, Flagyl is also effective against certain protozoal infections, including infections caused by the parasite Trichomonas vaginalis, which causes trichomoniasis, a sexually transmitted infection. It is also used to treat infections caused by other protozoa, such as Giardia lamblia and Entamoeba histolytica.

Dosage and Administration

The dosage of Flagyl will depend on the specific infection being treated, its severity, and the individual’s response to the medication. It is available in various forms, including tablets, capsules, and intravenous (IV) infusion. The medication should be taken as directed by a healthcare professional, and it is important to follow the recommended dosage and administration instructions.

Potential Side Effects and Precautions

Common side effects of Flagyl may include nausea, vomiting, diarrhea, headache, and metallic taste in the mouth. More serious side effects, although rare, may include allergic reactions, seizures, or a severe skin condition known as Stevens-Johnson syndrome. It is important to report any unusual or severe side effects to a healthcare professional.

Flagyl should not be taken by individuals who have certain medical conditions, such as liver disease, blood disorders, or a history of seizures. It may interact with other medications, so it is important to inform your healthcare professional about all the medications you are currently taking.

Consultation with Healthcare Professional

Flagyl is a prescription medication, and its use should be supervised by a healthcare professional. It is important to consult with a doctor to evaluate the specific infection, determine the appropriate treatment plan, and discuss the usage and potential side effects of Flagyl.

WARNING: Please consult with a healthcare professional or doctor for personalized advice and guidance regarding the use of Flagyl or any other antibiotic medication for the treatment of bacterial or protozoal infections. They will be able to provide specific instructions based on your medical history and individual needs.


  1. Jump up to:a b c “Metronidazole Use During Pregnancy”www.drugs.comArchived from the original on 1 January 2017. Retrieved 1 January 2017.
  2. Jump up to:a b c d e f g h “Flagyl, Flagyl ER (metronidazole) dosing, indications, interactions, adverse effects, and more”Medscape Reference. WebMD. Archived from the original on 7 April 2014. Retrieved 3 April 2014.
  3. Jump up to:a b c d e f Brayfield A, ed. (14 January 2014). “Metronidazole”Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 3 April 2014.[dead link]
  4. ^ Brayfield A, ed. (2017). Martindale: The Complete Drug Reference (39th ed.). London: Pharmaceutical Press. ISBN 978-0-85711-309-2.
  5. Jump up to:a b c d e f g h “Metronidazole”. The American Society of Health-System Pharmacists. Archived from the original on 6 September 2015. Retrieved 31 July 2015.
  6. Jump up to:a b c McDonald LC, Gerding DN, Johnson S, Bakken JS, Carroll KC, Coffin SE, et al. (March 2018). “Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)”Clinical Infectious Diseases66 (7): e1–e48. doi:10.1093/cid/cix1085PMC 6018983PMID 29462280.
  7. ^ “Safety in Lactation: Metronidazole and tinidazole”SPS – Specialist Pharmacy ServiceArchived from the original on 21 February 2020. Retrieved 22 February 2020.
  8. ^ Corey EJ (2013). Drug discovery practices, processes, and perspectives. Hoboken, N.J.: John Wiley & Sons. p. 27. ISBN 9781118354469Archived from the original on 8 September 2017.
  9. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  10. ^ Schmid G (28 July 2003). “Trichomoniasis treatment in women”. Archived from the original on 1 August 2015. Retrieved 1 August 2015.
  11. ^ “The Top 300 of 2020”ClinCalcArchived from the original on 12 February 2021. Retrieved 7 October 2022.
  12. ^ “Metronidazole – Drug Usage Statistics”ClinCalcArchived from the original on 13 April 2020. Retrieved 7 October 2022.
  13. Jump up to:a b c d e f Rossi S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3.
  14. ^ Geoghegan O, Eades C, Moore LS, Gilchrist M (9 February 2017). Clostridium difficile: diagnosis and treatment update”The Pharmaceutical Journal. Royal Pharmaceutical Society. Archived from the original on 7 March 2019. Retrieved 22 January 2018.
  15. ^ Dickman A (2012). Drugs in Palliative Care. OUP Oxford. p. 355. ISBN 9780191636103Archived from the original on 25 June 2022. Retrieved 29 August 2020.
  16. ^ Joesoef MR, Schmid GP, Hillier SL (January 1999). “Bacterial vaginosis: review of treatment options and potential clinical indications for therapy”Clinical Infectious Diseases28 (Suppl 1): S57–S65. doi:10.1086/514725PMID 10028110.
  17. ^ McCormick ME, Herbert MT, Pewitt EB (January 2022). “Gardnerella vaginalis prostatitis and its treatment: A case report”Urology Case Reports40 (Jan 2022): 101874. doi:10.1016/j.eucr.2021.101874PMID 34646744.
  18. ^ duBouchet L, Spence MR, Rein MF, Danzig MR, McCormack WM (March 1997). “Multicenter comparison of clotrimazole vaginal tablets, oral metronidazole, and vaginal suppositories containing sulfanilamide, aminacrine hydrochloride, and allantoin in the treatment of symptomatic trichomoniasis”. Sexually Transmitted Diseases24 (3): 156–160. doi:10.1097/00007435-199703000-00006PMID 9132982S2CID 6617019.
  19. ^ Leitsch D (September 2015). “Drug Resistance in the Microaerophilic Parasite Giardia lambliaCurrent Tropical Medicine Reports2 (3): 128–135. doi:10.1007/s40475-015-0051-1PMC 4523694PMID 26258002.
  20. ^ Zar FA, Bakkanagari SR, Moorthi KM, Davis MB (August 2007). “A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity”Clinical Infectious Diseases45 (3): 302–307. doi:10.1086/519265PMID 17599306.
  21. ^ Ryan KJ, Ahmad N, Alspaugh JA, Drew WL, Lagunoff M, Pottinger P, et al. (12 January 2018). Sherris medical microbiolog (Seventh ed.). New York. ISBN 978-1-259-85981-6OCLC 1004770160.
  22. ^ Rawat A, Singh P, Jyoti A, Kaushik S, Srivastava VK (August 2020). “Averting transmission: A pivotal target to manage amoebiasis”. Chemical Biology & Drug Design96 (2): 731–744. doi:10.1111/cbdd.13699PMID 32356312S2CID 218475533.
  23. ^ Shennan A, Crawshaw S, Briley A, Hawken J, Seed P, Jones G, Poston L (January 2006). “A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study”. BJOG113 (1): 65–74. doi:10.1111/j.1471-0528.2005.00788.xPMID 16398774S2CID 11366650.
  24. ^ D. Nori, J. M. Cain, B. S. Hilaris, W. B. Jones, J. L. Lewis: Metronidazole as a radiosensitizer and high-dose radiation in advanced vulvovaginal malignancies, a pilot study. In: Gynecologic Oncology. vol 16, issue 1, August 1983, S. 117–128, ISSN 0090-8258, PMID 6884824.
  25. ^ J.R.Sarna, S.Furtado, A.K.Brownell: Neurologic complications of metronidazole. In: Can J Neurol Sci. vol 40, issue 6, November 2013, S. 768-776, PMID 24257215.
  26. ^ J.Overgaard, H.S.Hansen, M.Overgaard, L.Bastholt, A.Berthelsen, L.Specht, et al.:A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) In: Radiother Oncol vol 46, issue 2, May 1998, PMID 9510041.
  27. ^ Cheung MJ, Taher M, Lauzon GJ (April 2005). “Acneiform facial eruptions: a problem for young women”Canadian Family Physician51 (4): 527–533. PMC 1472951PMID 15856972.
  28. ^ Cheung MJ, Taher M, Lauzon GJ (April 2005). “Acneiform facial eruptions: a problem for young women”Canadian Family Physician51 (4): 527–533. PMC 1472951PMID 15856972Archived from the original on 3 September 2021. Retrieved 3 September 2021.
  29. ^ Side Effects
  30. ^ “Flagyl metronidazole tablets label” (PDF). Archived (PDF) from the original on 22 January 2016. Retrieved 5 August 2015.
  31. ^ Iqbal SM, Murthy JG, Banerjee PK, Vishwanathan KA (April 1999). “Metronidazole ototoxicity–report of two cases”. The Journal of Laryngology and Otology113 (4): 355–357. doi:10.1017/s0022215100143968PMID 10474673S2CID 45989669.
  32. ^ Lawford R, Sorrell TC (August 1994). “Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report”. Clinical Infectious Diseases19 (2): 346–348. doi:10.1093/clinids/19.2.346PMID 7986915.
  33. Jump up to:a b Karamanakos PN, Pappas P, Boumba VA, Thomas C, Malamas M, Vougiouklakis T, Marselos M (2007). “Pharmaceutical agents known to produce disulfiram-like reaction: effects on hepatic ethanol metabolism and brain monoamines”. International Journal of Toxicology26 (5): 423–432. doi:10.1080/10915810701583010PMID 17963129S2CID 41230661.
  34. ^ Karamanakos PN (November 2008). “The possibility of serotonin syndrome brought about by the use of metronidazole”. Minerva Anestesiologica74 (11): 679. PMID 18971895.
  35. Jump up to:a b c d National Toxicology Program (2016). “Metronidazole” (PDF). Report on Carcinogens (Fourteenth ed.). National Toxicology Program (NTP). Archived (PDF) from the original on 9 February 2020. Retrieved 9 February 2020.
  36. Jump up to:a b “Metrogyl Metronidazole Product Information” (PDF). TGA eBusiness Services. Alphapharm Pty Limited. 8 May 2013. Archived from the original on 9 September 2016. Retrieved 3 April 2014.
  37. ^ Bendesky A, Menéndez D, Ostrosky-Wegman P (June 2002). “Is metronidazole carcinogenic?”. Mutation Research511 (2): 133–144. doi:10.1016/S1383-5742(02)00007-8PMID 12052431.
  38. ^ Beard CM, Noller KL, O’Fallon WM, Kurland LT, Dahlin DC (February 1988). “Cancer after exposure to metronidazole”. Mayo Clinic Proceedings63 (2): 147–153. doi:10.1016/s0025-6196(12)64947-7PMID 3339906.
  39. ^ “Metronidazole (IARC Summary & Evaluation, Supplement7, 1987)”INCHEM2. 3 March 1998. Archived from the original on 4 August 2020. Retrieved 12 September 2019.
  40. ^ Thapa PB, Whitlock JA, Brockman Worrell KG, Gideon P, Mitchel EF, Roberson P, et al. (October 1998). “Prenatal exposure to metronidazole and risk of childhood cancer: a retrospective cohort study of children younger than 5 years”Cancer83 (7): 1461–1468. doi:10.1002/(sici)1097-0142(19981001)83:7<1461::aid-cncr25>3.0.co;2-1PMID 9762949.
  41. ^ Friedman GD, Jiang SF, Udaltsova N, Quesenberry CP, Chan J, Habel LA (November 2009). “Epidemiologic evaluation of pharmaceuticals with limited evidence of carcinogenicity”International Journal of Cancer125 (9): 2173–2178. doi:10.1002/ijc.24545PMC 2759691PMID 19585498.
  42. ^ “Flagyl 375 U.S. Prescribing Information” (PDF). Pfizer. Archived from the original (PDF) on 7 August 2008.
  43. ^ “Agents Classified by the IARC Monographs, Volumes 1–124”International Agency for Research on Cancer (IARC). 8 July 2019. Archived from the original on 6 September 2019. Retrieved 12 September 2019.
  44. ^ Chen KT, Twu SJ, Chang HJ, Lin RS (March 2003). “Outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan”American Journal of Public Health93 (3): 489–492. doi:10.2105/ajph.93.3.489PMC 1447769PMID 12604501.
  45. ^ Cina SJ, Russell RA, Conradi SE (December 1996). “Sudden death due to metronidazole/ethanol interaction”. The American Journal of Forensic Medicine and Pathology17 (4): 343–346. doi:10.1097/00000433-199612000-00013PMID 8947362.
  46. ^ Gupta NK, Woodley CL, Fried R (October 1970). “Effect of metronidazole on liver alcohol dehydrogenase”. Biochemical Pharmacology19 (10): 2805–2808. doi:10.1016/0006-2952(70)90108-5PMID 4320226.
  47. ^ Williams CS, Woodcock KR (February 2000). “Do ethanol and metronidazole interact to produce a disulfiram-like reaction?”. The Annals of Pharmacotherapy34 (2): 255–257. doi:10.1345/aph.19118PMID 10676835S2CID 21151432the authors of all the reports presumed the metronidazole-ethanol reaction to be an established pharmacologic fact. None provided evidence that could justify their conclusions
  48. ^ Visapää JP, Tillonen JS, Kaihovaara PS, Salaspuro MP (June 2002). “Lack of disulfiram-like reaction with metronidazole and ethanol”. The Annals of Pharmacotherapy36 (6): 971–974. doi:10.1345/1542-6270(2002)036<0971:lodlrw>2.0.co;2PMID 12022894.
  49. ^ Flockhart DA (2007). “Drug Interactions: Cytochrome P450 Drug Interaction Table”Indiana University School of MedicineArchived from the original on 10 October 2007. Retrieved 4 January 2022.
  50. ^ Kudo T, Endo Y, Taguchi R, Yatsu M, Ito K (May 2015). “Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes”. Xenobiotica; the Fate of Foreign Compounds in Biological Systems45 (5): 413–419. doi:10.3109/00498254.2014.990948PMID 25470432S2CID 26910995.
  51. ^ Tirkkonen T, Heikkilä P, Huupponen R, Laine K (October 2010). “Potential CYP2C9-mediated drug-drug interactions in hospitalized type 2 diabetes mellitus patients treated with the sulphonylureas glibenclamide, glimepiride or glipizide”. Journal of Internal Medicine268 (4): 359–366. doi:10.1111/j.1365-2796.2010.02257.xPMID 20698928S2CID 45449460.
  52. Jump up to:a b c d Haberfeld H, ed. (2020). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Anaerobex-Filmtabletten.
  53. ^ Eisenstein BI, Schaechter M (2007). “DNA and Chromosome Mechanics”. In Schaechter M, Engleberg NC, DiRita VJ, Dermody T (eds.). Schaechter’s Mechanisms of Microbial Disease. Hagerstown, MD: Lippincott Williams & Wilkins. p. 28. ISBN 978-0-7817-5342-5.
  54. ^ Lamp KC, Freeman CD, Klutman NE, Lacy MK (May 1999). “Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials”. Clinical Pharmacokinetics36 (5): 353–373. doi:10.2165/00003088-199936050-00004PMID 10384859S2CID 37891515.
  55. ^ Bergan T, Leinebo O, Blom-Hagen T, Salvesen B (1984). “Pharmacokinetics and bioavailability of metronidazole after tablets, suppositories and intravenous administration”. Scandinavian Journal of Gastroenterology. Supplement91: 45–60. PMID 6588489.
  56. ^ Quirke V (29 December 2014). “Targeting the American market for medicines, ca. 1950s-1970s: ICI and Rhône-Poulenc compared”Bulletin of the History of Medicine88 (4): 654–696. doi:10.1353/bhm.2014.0075PMC 4335572PMID 25557515.
  57. ^ “G.D. SEARLE & CO. v. COMM | 88 T.C. 252 (1987) | 8otc2521326 | Leagle.com”Leagle. Retrieved 18 June 2019.
  58. ^ “2003:Pfizer and Pharmacia Merger”PfizerArchived from the original on 26 June 2019. Retrieved 18 June 2019.
  59. ^ Dickson S (July 2019). “Effect of Evergreened Reformulations on Medicaid Expenditures and Patient Access from 2008 to 2016”Journal of Managed Care & Specialty Pharmacy25 (7): 780–792. doi:10.18553/jmcp.2019.18366PMID 30799664.
  60. ^ “Metrogyl ER”. Medical Dialogues. Archived from the original on 17 April 2021. Retrieved 1 March 2021.
  61. ^ “Metronidazole Brands”. Medex. Archived from the original on 24 November 2021. Retrieved 24 November 2021.
  62. ^ Ebel K, Koehler H, Gamer AO, Jäckh R. “Imidazole and Derivatives”. Ullmann’s Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a13_661.
  63. ^ Actor P, Chow AW, Dutko FJ, McKinlay MA. “Chemotherapeutics”. Ullmann’s Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a06_173.
  64. ^ Kraft MY, Kochergin PM, Tsyganova AM, Shlikhunova VS (1989). “Synthesis of metronidazole from ethylenediamine”. Pharmaceutical Chemistry Journal23 (10): 861–863. doi:10.1007/BF00764821S2CID 38187002.
  65. ^ Barr SC, Bowman DD, Heller RL (July 1994). “Efficacy of fenbendazole against giardiasis in dogs”. American Journal of Veterinary Research55 (7): 988–990. PMID 7978640.
  66. ^ Hoskins JD (1 October 2001). “Advances in managing inflammatory bowel disease”DVM NewsmagazineArchived from the original on 31 December 2013. Retrieved 28 December 2013.
  67. ^ Plumb DC (2008). Veterinary Drug Handbook (6th ed.). Wiley. ISBN 978-0-8138-2056-9.
  68. ^ “Metronidazole”. Drugs.com. Archived from the original on 24 June 2013.